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Another mitochondrial ROS-sensitive marker, Aconitase was significantly decreased (50%60%) in both the tissues of GK rats (Figure 6B)

Nonetheless, the European Crohns and Colitis Organisation released a consensus statement to support the use of thiopurines as a monotherapy or an adjunct to infliximab in CD and steroid-dependent UC, noting that thiopurines were significantly more effective than aminosalicylates in curbing flares of UC ( Thiopurines are also commonly used as adjunct therapy in a step-down strategy for treating severe CD