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Safety, tolerability, and pharmacokinetics of KNS-760704 (dexpramipexole) in healthy adult subjects

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Notably, pharmacological inhibition of the PI3K-AKT-mTOR pathway reverses Sunitinib- and Sorafenib-resistant phenotypes driven by aberrant AKT activation, underscoring that this pathway represents a potential therapeutic node to overcome drug resistance (267, 272)