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1A Schematic illustration of pathways regulated by NNMT, including the NAD+ biosynthesis salvage pathway starting from NA as a precursor that feeds into energy metabolism, methionine cycle that regulates intracellular SAM concentrations and thus cellular epigenetic modifications and polyamine flux, and clearance of NA by conversion to 1-MNA and excretory products

Whether conditioned medium from PTX-resistant GC cells could transfer the resistance phenotype was then investigated

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Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246