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10.3389/fphar.2024.1363202 145 XiangY.GuoZ.ZhuP.ChenJ.HuangY

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By comprehensively correcting disorders across multiple metabolite axes through dietary interventions (such as supplementing specific prebiotics and fibers), probiotic/postbiotic therapies, or small-molecule inhibitors (such as targeting microbial enzymes CutC/D to inhibit TMAO generation), it is expected that more fundamental and effective management of liver diseases can be achieved

And so I think thats the big reason that theres so much controversy is that for whatever reason, theres some people who just dont want to look at the older trials that were very long and theyre spending all their time looking at these very short term trials