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Various factors may have contributed to these mixed results, including participant heterogeneity, compliance issues, and the aggressive placebo response often seen in obesity trials where lifestyle modification is encouraged

[PubMed: 658418] 10

Insulin spikes may compete with AOD-9604's lipolytic signaling

In white adipose tissue, blocking NNMT elevated resting calorie burn, decreased adiposity, and improved insulin sensitivity in rodent models, independent of diet or activity changes (Kraus et al., Nature Medicine )

BPC-157 (Body Protection Compound 157) is a synthetic pentadecapeptide 15 amino acids long derived from a protective protein naturally found in human gastric juice