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Meanwhile, a retrospective review of 95 eyes of 52 patients in which latanoprostene bunod was substituted for prostaglandin demonstrated that latanoprostene bunod was more efficacious than a prostaglandin that does not contain nitric oxide and found that latanoprostene bunod is additive in patients on multiple ocular hypotensive medications

For example, the Wnt/-catenin signaling pathway plays a critical role in maintaining stemness by activating transcriptional programs that promote self-renewal and inhibit differentiation in both normal cells and CSCs

& Matsuda, Y

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