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For example, in the case of mitochondrial fusion, the overexpression of Fzo1A/B or MFN1/2 prevents excessive fragmentation of mitochondria

It occurs mainly through metabolism in brown fat and to a lesser degree in skeletal muscle, liver, brain, and white fat

Apart from regulating survival and proliferation, some of these alterations in signal transduction can also directly affect cellular metabolism

Therefore, an inexpensive test should be made available in countries where malaria is endemic to determine the deficiency reliably, including its heterozygous form

IannittiRGFloridiALazzariniATantucciARussoRRagoneseFet al