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For example, SeMet is better absorbed than inorganic Se compounds like sodium selenite, and it has a longer half-life in the body, making it a preferred form for supplementation [6]

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However, it should be noted that although NNN and NMA can cause liver tumors, liver is not the main target organ for these substances, for which the upper gastrointestinal tract or nasal cavity are the most sensitive sites for carcinogenicity (Hecht et al

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Finally, we address critical considerations such as therapeutic windows and biomarkers of ferroptosis, which are prerequisites for successful translation into clinical oncology