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Clinical diagnosis primarily relies on proteinuria and eGFR, yet these lack sufficient sensitivity for early nonproteinuric DN (NP-DN)

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doi: 10.1016/j.neurol.2019.08.005 72

Stabilization of mutant cu/Zn superoxide dismutase (SOD1) protein by coexpressed wild SOD1 protein accelerates the disease progression in familial amyotrophic lateral sclerosis mice