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The liver represents the largest reservoir of glutathione, which is crucial for the liver's Phase I and Phase II detoxification functions

Moreover, the UA transportersURAT1, GLUT9, and ABCG2play crucial roles in regulating UA levels, with dysfunctional transporters leading to abnormal serum UA levels, as observed in hypouricemia and hyperuricemia

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PINK1 deficiency in -cells increases basal insulin secretion and improves glucose tolerance in mice