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Hydrocodone reaches peak plasma concentration approximately 1.3 hours after ingestion and produces analgesic effects within 30 to 60 minutes

This is a preview of subscription content, access via your institution Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription $32.99 / 30 days cancel any time Subscribe to this journal Receive 12 digital issues and online access to articles $119.00 per year only $9.92 per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout References Lee, N

Ramachandran C, Quirin K-W, Escalon E, Melnick SJ (2014) Improved neuroprotective effects by combining Bacopa monnieri and Rosmarinus officinalis supercritical CO 2 extracts

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Aberrant calcium signals in reactive astrocytes: a key process in neurological disorders