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Under these circumstances, BAP31 is cleaved with consequent formation of the p20 fragment, which activates the mitochondrial apoptotic events such as cytochrome c release, resulting in activation of the intrinsic apoptotic pathway [123, 125]

Trial design Forty-eight healthy participants (79% male, median age: 49 years, BMI: 29.9 kg/m2, body weight: 92 kg) were randomized (3:1) within three cohorts

2008;295:G987G995

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