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Cancer 20 , 174186 (2020)

The accumulation of nondegraded metabolites, as a consequence of the disrupted metabolic pathways, may lead to inflammasome activation triggering macrophage overactivation

Methylmalonyl-CoA and propionyl-CoA competitively inhibit NAGS, reducing NAGS activity by over 30% and consequently decreasing N-acetylglutamate (NAG) production