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This ratio suggests that a generally higher NAD+ to NADH ratio is favourable

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

Free Radical Biol Med (2006) 41:133850

It also identified several polymorphisms that play into fibroid development, including several that affect oncogenesis, immune factors, cell metabolism and migration, collagen formation, and endogenous antioxidant systems like Nrf2