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Some patients may require an even higher dose of 2 mg weekly for optimal effect, particularly for weight management indications, though this should be approached cautiously with careful monitoring for adverse effects

Whilst folic acid supplementation is routinely advised before conception and during early pregnancy to prevent neural tube defects, folate can mask the haematological signs of B12 deficiency

Suboptimal B12 causes brain fog, difficulty concentrating, mood changes, tingling extremities, and progressive neurological decline

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