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Vesterdal LK, Jantzen K, Sheykhzade M, Roursgaard M, Folkmann JK, Loft S, et al

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Indeed, because more than 100 proteins have been reported as TG2 substrates and because TG2 has broad substrate specificity, the GST tag could be crosslinked with a number of cellular proteins 21

Glutathione protective mechanisms Recently, studies have further demonstrated the negative effects of oxidative stress and impaired redox signaling in the onset of OA, aggravating significant oxidative damage of cellular structures and vital molecules in cartilage as well as other tissues