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Table 1 indicates the combination of quercetin with current antidiabetic drugs acting by different mechanisms and streptazotocin-induced animal studies further show their efficacy in reducing blood glucose levels in type 2 diabetic rats/mice

Different GLP-1/glucagon multi-agonists are currently under investigation (135)

In addition, melatonin also increases the expression of liver kinase B1 (LKB1) in renal tissue and elevates the level of p-AMPK in the STZ-induced DKD model and the NEK-52E cell treated with HG

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Czajka A, Kania EM, Genovese L, Corbo A, Merone G, Luci C, et al