glutathione and acetaminophen toxicity Clinically relevant therapeutic approaches against hepatotoxicity acute liver failure Too much paracetamol = dangerous

Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem 10 days of MCQ! Day 3: Acetaminophen Overdose Answer: C N acetylcysteine (NAC) NAC is the antidote for acetaminophen overdose. It works by replenishing hepatic glutathione stores, which are rapidly depleted Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S transferase Pi PNAS What causes hepatic necrosis from acetaminophen overdose? Acetaminophen Pathway (toxic doses), Pharmacokinetics

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