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MCT1, highly expressed by oligodendrocytes, facilitates lactate export to the axon, where it is taken up by axonal MCT2 (Figure 4b

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Excessive free radicals are produced in the PQ redox cycle, these free radicals have the ability to extract hydrogen from polyunsaturated fatty acids leading to lipid peroxidation, which is thought to be the most significant early stage in the pathophysiological process of PQ-induced organ damage (Dinis-Oliveira et al

and Set limits while exploring strategies to solve the problem at hand