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Katsuyama Y, Taira N, Yoshioka M, Okano Y, Masaki H

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Silymarin (100 mg/kg) decreased cardiac fibrosis, collagen deposition, and dysfunction in diabetic mice, whereas silibinin used ERK1/2 MAPK signalling to control hypertrophic responses in cardiomyocytes ( 3.3.3 Renoprotective activity The oxidative and inflammatory burden to which the kidney is exposed is high due to its role in xenobiotic detoxification

Spermidine is involved in growth and proliferation, organogenesis, transcription and translation, the control of the activity of ion channels, immune response, initiation of autophagy, prevention of senescence, response to oxidative, osmotic, and other stresses, thus being one of the essential metabolites 12,13,14,15,16