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doi: 10.1016/j.jaad.2018.01.020

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[PubMed Citation] Cescon DW, Juurlink DN

With obesity, levels of MCP-1 and TNF- increase in VAT before macrophage infiltration, suggesting a highly proinflammatory phenotype of the visceral depot prior to infiltration of immune cells and macrophage phenotype switch [77]

Chemically, these compounds are not related to naturally occurring cannabinoids, but their actions in the body create a high that resembles marijuana in some ways