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Finally, they presented this slide showing that Amylin seems to act on two brain regions, the area postrema (AP) and the arcuate nucleus (ARC) and that with damage to the AP you lose essentially all of the actions of amylin

(2021) "Thymosin 4: A Potential Anti-Aging Factor" Frontiers in Endocrinology Goldstein et al

Drugs fitting this profile (like TB-500) typically require high, sustained plasma concentrations to maintain a significant level of receptor or binding site saturation

Others find this increases lightheadedness or nausea

This kind of "mopping up" activity can be beneficial for those dealing with headaches and/or migraines, inflammation, cold hands and feet, sore muscles and joints, fatigue, lack of motivation, memory challenges, feeling lightheaded when standing, brain fog, as well as symptoms of Chronic Fatigue and/or Fibromyalgia