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Without therapy, the rats with simultaneous occlusion of the superior mesenteric vein and artery exhibited subarachnoid haemorrhage at the base of the brain in the cerebellar area and more karyopyknotic cells in the cerebral and cerebellar cortex, hippocampus, and hypothalamus/thalamus (Figure 13 and Figure 14)

Furthermore, developing small molecule inhibitors targeting BCAA transporters in tumor cells and immunosuppressive cells allows CD8 + T cells to obtain amino acid metabolic advantages in the immune microenvironment and enhance the anti-tumor effect

Indeed, other tissues from the Gclc KO mice, including the kidney, pancreas, and spleen, were also histologically similar to tissues from the Gclc WT mice (Fig

Spadaro, D

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