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Published on November 5th, 2025

some of these cells create brainbody barriers (perineurial and subperineurial surface glial cells), others cover neuronal somata (cortex glia) and some ensheath synapses in neuropil (astroglia-like cells) 32,33

doi: 10.1016/j.bj.2019.05.003 105 KimS-HParkM-J

BelzerCde VosWM

Additionally, strategies such as low-dose optimization, structural analog design for enhanced CNS selectivity, and targeted drug delivery systems hold promise for improving Tozasertibs therapeutic index