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A2-APM treatment efficacy is dependent on CD8 + T cells Since our results above demonstrated that T cells play an important role in A2-APM anti-GBM efficacy, next we investigated which subtype of T cells (CD4 or CD8) plays a dominant role in A2-APM antitumor therapy

Melatonin stimulates cell apoptosis via the regulation of many apoptosis facilitators, including mitochondria, cytochrome c, Bcl-2, production of reactive oxygen species, and apoptosis receptors