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110,111 Through a series of complex disruptions of the genome, cells acquire the accumulation of deleterious alterations irreversibly to survive in purifying selection (removing deleterious genetic variations) of human germline evolution, further obtaining fitness, attenuating tumor cell attrition and evolving to malignancies

Mitochondrial function and efficient energy metabolism

Introduction The lifestyles of Aspergillus species associated with plants range from saprophytes and symptomless endophytes to weak and opportunistic phytopathogens

A recent study has shown that the overexpression of wild-type or PD-associated A30P and A53T -synuclein mutants significantly disrupts MLCS tethering (Giamogante et al., 2024)

(86) found that Cistanches herba extract upregulated the level of mitofusin-2 (Mfn2) and the Bcl-2/Bax ratio, restored mitochondrial enzyme activity and MMP in ovarian tissues, and primarily mediated these effects through the inhibition of apoptosis and improvement of mitochondrial function to intervene in ovarian aging