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Protein native mass was detected by using TripleTOF 5600 + (AB SCIEX, Framingham, MA, USA)

Mikhaylov D, Pavel A, Yao C, Kimmel G, Nia J, Hashim P, Vekaria AS, Taliercio M, Singer G, Karalekas R, Baum D, Mansouri Y, Lebwohl MG, Guttman-Yassky E (2019) A randomized placebo-controlled single-center pilot study of the safety and efficacy of apremilast in subjects with moderate-to-severe alopecia areata

AA can be used for the synthesis of prostaglandins, which can have different types of vasodilating effects

NO can react with glutathione to form S-nitrosoglutathione (GSNO), which effectively transduces NO signal

The highly reactive oxygen intermediates can cause serious chemical damage to DNA, proteins, and unsaturated lipids and can lead to cell death