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Further correlations between gut microbiota and DN phenotypes are detailed in Table 2

Regardless of the type, elevated blood sugar levels can lead to damage in various systems and organs of the body, resulting in complications such as cardiovascular diseases, neuropathy, kidney diseases, retinopathy, and foot complications

While some retrospective studies suggest that metformin may confer a survival benefit for diabetic patients with solid tumors, including PDAC, randomized controlled trials have not found significant benefits for PDAC patients when metformin is combined with gemcitabine [109, 113]