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Genes associated with resistance include those conferring target-site resistance (e.g., mutations in the voltage-sensitive sodium channel ( VSSC ) gene, also known as kdr mutations 3 ) or metabolic resistance (e.g., glutathione S-transferase ( GST ) 1 and cytochrome P450 ( P450 or CYP ) genes 4 )

Aged mice were divided into control and treatment groups, with the latter receiving intraperitoneal injections of FOXO4-DRI at doses of 0.5 mg/mL and 5 mg/kg every other day for 30 days, while controls received PBS

Systematic collection of adverse events was not done in all of these studies and interpretation of causality is limited due to the lack of a control group and due to circumstances of administration (e.g., use in fire victims)

B-Complex B1, B2, B3, B5, B6 Stress resilience, immune & nervous system support

Rao BG, Rao YV, Rao TM (2013) Hepatoprotective and antioxidant capacity of Melochia corchorifolia extracts