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The variant in ANKK1 gene is associated with increased activity of the final enzyme named aromatic L-amino acid decarboxylase, which is involved in the biosynthesis of dopamine ( Cytochrome P450 2E1 gene This gene belongs to a member of the cytochrome P450 superfamily of enzymes that catalyze many reactions, including drug metabolism, synthesis of cholesterol, and lipids, and being induced by ethanol