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[128:22] Andrew Huberman And in species like dogs, where there's tremendous variation in the amount of IGF one that's made between, say, a Chihuahua and a Great Dane, the breed that makes more IGF1 downstream growth hormone, of course, lives a lot shorter lives than smaller versions of the same species

While on the other hand there exist the leak pathway that regulates the passage of larger molecules and is measured by the passage of fluorescent tracers (FITC) across epithelial monolayers

Sci Rep 16(1):5727

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