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The transition of parental cells to IDTCs/DTPs may require activation of key signaling pathways such as pan-PI3 K, Akt, mTOR, FGFR, IGF1R, or the downstream STK11, B2M, APC, mTOR, KEAP1and JAK1/2 that confer ICI tolerance

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CD44 plays a role in the pathogenesis of intestinal diseases, and differential expression of secretory mucin MUC5AC enhances tumorigenesis and confers chemotherapy resistance through the CD44/-catenin/p53/p21 signaling pathway (Pothuraju et al., 2020)

In-vitro and in-vivo anti-breast cancer activity of synergistic effect of berberine and exercise through promoting the apoptosis and immunomodulatory effects