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Clinical confirmation in humans is still pending

Proc Natl Acad Sci U S A 1990;87:7245-7249

the cofactor or precursor thereof comprises niacinamide

Lactams are important structural motifs found in many natural products, pharmaceuticals, and biologically active compounds

[52] While elders are more sensitive to GH, and thus more susceptible to the side effects of replacement with rhGH, stimulating production and secretion of endogenous GH with Sermorelin offers the advantage of a more physiological approach to increasing GH pulsatility while reducing risk for side effects