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It is reported that patients with acute myocardial infarction has a three times higher prevalence of depression compared to the general population, while patients with New York Heart Association (NYHA) class IV HF exhibit a four-fold higher incidence of depression than those with NYHA class I HF [88]

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STAT3 is responsible for mediating cellular responses to growth factors, interleukins, etc., and plays a part in cellular processes like apoptosis 42 , while also acting as a regulator of inflammatory responses 43