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Additionally, the modest sample size limits generalizability and statistical power, and replication in larger cohorts is required

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(Figure 4) FIGURE 4 4.4.1 Posttranslational modifications of histones Among the explored epigenetic factors, post-translational modifications of histones, especially histone acetylation and methylation, which can be modulated by ketone bodies, have attracted the most attention due to their potential as therapeutic targets for heart failure (Li et al., 2020a