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The NLRP3 inflammasomes are central to the initiation of inflammatory responses by activating caspase-1 and promoting the release of pro-inflammatory cytokines, particularly interleukin (IL)-1 and IL-18

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Eligible participants were stratified block randomized (i.e., on PTSD and AUD severity) to 12 weeks of NAC (2400 mg/day, n = 18) or matched placebo ( n = 26)