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[6] These analyses are useful, but they are the weakest tier for a two-drug verdict: indirect comparisons inherit every difference between the underlying trials and cannot substitute for a randomised head-to-head

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In Fmr1 -KO mice, in which pharmacological intervention with PD158780 (ErbB inhibitor) led to a reduction in repetitive behaviors, electrophysiological experiments showed that the behavioral effects were due to a reduction in mGluR1/5-activated currents (I DHPG ) and the co-occurrence of spontaneous firing hyperactivity and hyperexcitability of SNpc DA neurons [57]

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