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TB-500 (synthetic TB4) has been clinically tested for its wound healing potential, with the following two studies worth noting: In a randomized, double-blind, placebo-controlled study with dose escalation, patients suffering from venous stasis ulcers were administered synthetic TB4 locally over a period of 84 days

Acknowledgments The authors are thankful all supports provided by Princess Nourah bint Abdulrahman University Researchers Supporting Project number (PNURSP2025R127), Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia

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