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While hormone optimization has become widely recognized, another important factor is the decline of specific regenerative peptides in the body

But we don't have large, well-controlled human trials

137,138 The clinical phenomenon of heart failure commonly manifests as pathological myocardial hypertrophy, inflammation, cell death, and scar formation and ultimately leads to the inability of cardiac function to adapt to the needs of the systemic blood supply

F.LobineD.et al (2020)

Experimental and clinical data suggest that melatonin exerts its anti-inflammatory effects by modulating both pro- and anti-inflammatory cytokines in various pathophysiological situations 73,74