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This organ distribution difference enables the brain, kidneys and small intestines to sequester GSH from the blood circulation to meet the need of these organs for GSH, and provide a solid foundation for developing organ selective agents for these organs in general

10.7759/cureus.14284 Rohit Gupta, Maulin Patel, Luis Caceres, Mayur Rali, Parth Rali

In order to alleviate ER stress, cells trigger the unfolded protein response (UPR) (Supplementary Box 1) , which serves as a critical cell survival mechanism, involving various adaptations, importantly including reduction of protein load via decreasing protein synthesis (see next section)

ROC curves were generated via Monte-Carlo cross-validation (MCCV) using balanced sub-sampling

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