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10 BiagiottiS.AbbasF.MontanariM.BarattiniC.RossiL.MagnaniM.et al (2023)

There have also been reports that some plant extracts used in traditional or indigenous medicine, such as those of American herb Eriodictyon angustifolium or the Chinese plant Polygonum multiflorum can slow greying, and re-pigmentation has even been observed in response to injuries to the scalp during skin cancer surgery

indicum extract exhibited decreased levels of TNF-, IL-1, IL-6, and NF-B p65 protein

The low permeability of paracellular pathways is mainly determined by tight junctions (TJs), which mainly consist of densely distributed transmembrane protein claudin (especially claudin-5), occluding, tricellulins, junctional adhesion molecules, and intracellular support proteins such as zona occludens (ZO) (Haseloff et al., 2015

The mitochondrial repair mechanism is further declined by reducing mitochondrial oxygen consumption efficiency, thus forming a vicious circle [17]