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[DOI] [PubMed] [Google Scholar] 163.Ertunc ME, Sikkeland J, Fenaroli F, Griffiths G, Daniels MP, Cao H, et al

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Taking ibuprofen alongside other nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin or naproxen can raise the risk of gastrointestinal issues such as ulcers and bleeding

Peripherally, it slows gastric emptying, so nutrients hit the circulation more slowly and satiety persists longer

But the actual costs can get complicated, especially for off-label uses