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Chang and colleagues (Journal of Applied Physiology, 2011) reported that BPC-157 promotes tendon outgrowth, cell survival, and migration in cultured tenocytes, findings that have been replicated by multiple independent groups and form the basis for its prominence in musculoskeletal-repair research

doi: 10.1002/jor.22133, 50

This may be linked to statins potential effects on cognition 44,45,46 , including memory loss, which prompted the US Food and Drug Administrations 2012 warning on cognitive adverse effects

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This functional difference is further reflected in clonogenicity assays, where Tie2 + NPPCs form spheroid colonies in 3D culture, while Tie2 cells generate spread, fibroblastic colonies [42, 43]