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These findings have led to the consensus that elevated plasma total homocysteine is a modifiable risk factor for development of cognitive decline, dementia, and Alzheimers disease in older persons

Appl Biochem Biotechnol 196:75037533

Randomised clinical trial: vercirnon, an oral CCR9 antagonist, vs

Together, these interconnected pathways establish a self-perpetuating cycle that accelerates biological aging

Cytokines secreted by activated macrophages can also interfere with myelination and the expression of related genes (247), preventing myelin sheath repair and causing disability (248)