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Cells , 13 (22), 1864

152 Hepatoprotective activity Treatment of albino rats with aqueous leaf extract of Jamun for 7 days before carbon tetrachloride (CCl 4 ) treatment reduced aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels, indicating its hepatoprotective activity

3.2.2 TGF--induced mitochondrial ROS production Mitochondria are the primary intracellular source of ROS, and TGF-1 markedly enhances their production across multiple cell types, contributing to apoptosis, senescence, epithelialmesenchymal transition (EMT), and fibrotic gene expression associated with myofibroblast differentiation [58]

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