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Gut microbiota might act as a negative feedback mechanism to maintain the homeostasis of BAs and PUFAs via FGF19 signalling and PUFA saturation, respectively

Tatone C, Di Emidio G, Vitti M, Di Carlo M, Santini S, DAlessandro AM, et al

The ideal biomaterials must not cause apparent toxicity, inflammation, or even severe host response while at the same time providing enough mechanical support (73)