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In the hippocampus of individuals with Alzheimer's disease (AD), the expression of PGC-1, NRF1, NRF2, and TFAM is significantly decreased, indicating impaired mitochondrial biogenesis (203)

Literally every biochemical reaction in our cells requires us to be in this reduced state

This molecule is often referred to as the "master antioxidant" because it is found in high concentrations in nearly every cell and is responsible for neutralizing free radicalsunstable molecules that can cause oxidative stress and damage cellular structures

The largest trial involving DSIP to date, which included a total of 107 volunteers, reported that the peptide was generally well-tolerated with mostly minor side effects, which included [8]: Low blood pressure Increased sweating Headache Nausea Vertigo Considering that the drop in blood pressure was reported as moderate to severe in some patients, researchers should consider hypotension as a potentially exclusionary criterion for DSIP research