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Under hypoxia or metabolic stress, HIF-1 activation induces multi-drug resistance by upregulating efflux transporters such as P-glycoprotein (P-gp/MDR1), enforcing G1 cell-cycle arrest, and stimulating antioxidant and DNA repair programs that confer radioresistance [326, 327]

Further research targeting these genes may lead to a better understanding of the mechanisms underlying the onset of cataract

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Int J Res Pharm Sci 2019;10(1):523-530

Most reported side effects are mild