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At concentrations lower than those of DON, JHU395 has been found to decrease the growth and increase the apoptosis of high-MYC medulloblastoma cell lines, thereby prolonging the survival of treated animals (100)

and reduce colon inflammation and intestinal epithelial apoptosis by inhibiting the levels of Bax and caspase 9 in colon tissue

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The template DNA was then digested with Dpn I and the plasmids were cloned in strain XL1-Blue

We knocked down PRMT1 in HK-2 cells using a lentiviral vector and overexpressed PRMT1 in vitro using an adenoviral (ADV) vector carrying PRMT1 DNA