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Our group has recently described that NKX2-1 induces dependency on de novo ser/gly synthesis to control ATP supply, nucleotide metabolism and redox homeostasis

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Apart from the antioxidant protections, a trial on oral supplementation during the periods of high-intensity exercises also showed benefits in the modulation of inflammatory signaling, the pro- and anti-inflammatory cytokines released, together with a potential pro-angiogenic effect on hematologic parameters such as hemoglobin, red blood cell number, vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF) [74]

The investigators in this study are in no way promoting binge drinking, however, it must be recognized that some individuals are more prone to hangovers than others, even when consuming smaller amounts of alcohol and alcohol intoxication and hangover symptoms are significant issues in society today